A large number of small open reading frames (sORFs) are predicted to exist in the transcripts previously annotated as non-coding RNAs or untranslated regions of protein-coding genes. Emerging evidence show that sORFs may encode micropeptides with less than 100 amino acids. To date, only a small fraction of the putative micropeptides has been functionally characterized. More extensive investigat...
Colorectal cancer (CRC) is a genetic disease with accumulated genetic alterations during the progression and invasion. CRC is highly aggressive and is the third leading malignance in the world population, and its incidence has been a health care challenge. Thus, there is an urgent need to identify more molecular biomarkers for CRC. Also, it is critical to explore the molecular mechanisms involv...
Aerobic glycolysis is considered a hallmark feature of cancer. Recently, Prof. Bin Wu's team from the Third Affiliated Hospital of Sun Yat-sen University published an original article entitled "Aerobic glycolysis enhances HBx-initiated hepatocellular carcinoma via NF-κBp65/HK2 signaling" online in the Journal of Experimental & Clinical Cancer Research on Nov. 21th, revealed a key mechanism of ...
Recently, the research team directed by Prof. Shicheng Su from Sun Yat-sen Memorial Hospital, Sun Yat-sen University, revealed a new mechanism of the pro-tumor effect mediated by Fcγ receptor signals in non-leukocyte cells. This work entitled "CD16+ Fibroblasts Foster a Trastuzumab-Refractory Microenvironment That is Reversed by VAV2 Inhibition" was published online in Cancer Cell on Nov. 14th.
Recently, Prof. Kuang Ming's team (Center for Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University) and Prof. Lin Shuibin's team (Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University) co-published a research article entitled “Targeting tumor-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves...
"Emergency! The patient transferred from Haizhu's lockdown zone had a fishbone stuck in the throat for more than 10 hours," said a medical staff member of the Sun Yat-sen Memorial Hospital, Sun Yat-sen University.
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