The rediscovery of N6-deoxyadenosine (6mA) in eukaryotic genomes has sparked interest in its potential as a new epigenetic marker. In recent years, 6mA has been identified in various eukaryotes, including plants, vertebrates, and mammals. However, limitations in current methods, particularly the inability to accurately identify the location of 6mA, have hindered further research into its mechan...
At present, the frequency of flood disasters has increased sharply around the world, and the scope of disasters has expanded year by year, and it has become one of the most important agricultural disasters. Prolonged plant immersion in flood/flooded environments can lead to a significant decrease in rhizosphere oxygen content, resulting in hypoxic stress (hypoxia); Long-term flooding stress wil...
Some observational studies had found that shift work would increase risks of metabolic disorders, cancers, and cardiovascular diseases by affecting sleep time, circadian rhythm, and other mechanisms, but there was no homogeneous evidence of such an association between shift work and incident dementia, which has important public health implications for the physical and mental health of shift wor...
A large number of small open reading frames (sORFs) are predicted to exist in the transcripts previously annotated as non-coding RNAs or untranslated regions of protein-coding genes. Emerging evidence show that sORFs may encode micropeptides with less than 100 amino acids. To date, only a small fraction of the putative micropeptides has been functionally characterized. More extensive investigat...
Colorectal cancer (CRC) is a genetic disease with accumulated genetic alterations during the progression and invasion. CRC is highly aggressive and is the third leading malignance in the world population, and its incidence has been a health care challenge. Thus, there is an urgent need to identify more molecular biomarkers for CRC. Also, it is critical to explore the molecular mechanisms involv...
Aerobic glycolysis is considered a hallmark feature of cancer. Recently, Prof. Bin Wu's team from the Third Affiliated Hospital of Sun Yat-sen University published an original article entitled "Aerobic glycolysis enhances HBx-initiated hepatocellular carcinoma via NF-κBp65/HK2 signaling" online in the Journal of Experimental & Clinical Cancer Research on Nov. 21th, revealed a key mechanism of ...
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