Research News
-
Neuron | Professor Yamei Tang's team uncovers a chemotactic action of brain resident microglia in recruiting peripheral CD8+ T lymphocytes and driving brain injury
Radiation-induced brain injury (RIBI) remains as the most serious medical complication in head and neck cancer patients who received cranial radiotherapy. The clinical manifestations of RIBI include cognitive impairment, epilepsy, and pathological changes such as brain edema and tissue necrosis, which can occur within 3-5 years after the radiotherapy. The progressive development of brain lesion...
January 15, 2023
-
Did Shift work increase the risk of dementia? A new discovery made by Prof. Yamei Tang's team
Some observational studies had found that shift work would increase risks of metabolic disorders, cancers, and cardiovascular diseases by affecting sleep time, circadian rhythm, and other mechanisms, but there was no homogeneous evidence of such an association between shift work and incident dementia, which has important public health implications for the physical and mental health of shift wor...
January 5, 2023
-
Jian-Hong Fang & Shi-Mei Zhuang's group identifies a novel mitochondrial micropeptide associated with liver cancer metastasis
A large number of small open reading frames (sORFs) are predicted to exist in the transcripts previously annotated as non-coding RNAs or untranslated regions of protein-coding genes. Emerging evidence show that sORFs may encode micropeptides with less than 100 amino acids. To date, only a small fraction of the putative micropeptides has been functionally characterized. More extensive investigat...
December 30, 2022
-
Professor Mong-Hong Lee and Dr. Qingxin Liu's group discovered new target for colorectal cancer intervention
Colorectal cancer (CRC) is a genetic disease with accumulated genetic alterations during the progression and invasion. CRC is highly aggressive and is the third leading malignance in the world population, and its incidence has been a health care challenge. Thus, there is an urgent need to identify more molecular biomarkers for CRC. Also, it is critical to explore the molecular mechanisms involv...
December 21, 2022
-
Prof. Bin Wu's team revealed a key mechanism of aerobic glycolysis in the process of hepatitis B virus-related HCC
Aerobic glycolysis is considered a hallmark feature of cancer. Recently, Prof. Bin Wu's team from the Third Affiliated Hospital of Sun Yat-sen University published an original article entitled "Aerobic glycolysis enhances HBx-initiated hepatocellular carcinoma via NF-κBp65/HK2 signaling" online in the Journal of Experimental & Clinical Cancer Research on Nov. 21th, revealed a key mechanism of ...
December 6, 2022