Lin Dongxin
Professor
Principle Investigator
lindx@sysucc.org.cn
Prof. Lin obtained his medical Master degree at Beijing Medical University in 1986 and received post-doc training on chemical carcinogenesis and molecular epidemiology at WHO International Agency for Cancer Research (Lyon, France) and FDA National Center for Toxicological Research (Arkansas, USA) from 1989 to 1994. He started to serve as associate professor from 1995 and full professor from 1997 in the Department of Etiology & Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College. He was elected as academician of the Chinese Academy of Engineering in 2013. Prof. Lin have been serving as joint Professor at Sun Yat-sen University Cancer Center since 2015.
He has been working on cancer genetics and genomics, especially on esophageal cancer and pancreatic cancer with more than 260 publications in peer-reviewed journals including Nature, Nature Genetics, Cancer Cell, Cell Metabolism, etc. He has been honored with awards for his research work including the National Natural Science Award in 2006, the National Prize for Progress in Science and Technology in 2008, the National Natural Science Award in 2013, the National Prize for Progress in Science and Technology in 2013, etc.
Research interests
Molecular mechanism of tumorigenesis and genetic susceptibility of cancer; gene-environment interaction in cancer; the effect of genomic alterations on cancer treatment.
Education
1977-1980: Medical Student, Shanghai Medical University, Shanghai, China
1983-1986: Medical Graduate Student, Beijing Medical University, Beijing, China
Publications
1.Liu J, He X, Deng S, Zhao S, Zhang S, Bai R, Xue C, Zeng L, Zhao H, Zhou Y, Xu Z, Liu S, Chen Z, Zhou Q, Li M, Zhang J, Huang X, R Chen, Wang L*, Lin D*, Zheng J*. QDPR deficiency drives immune suppression in pancreatic cancer. Cell Metabolism. 2024 May;36(5):984-999.e8.
2.Li R, Zhao H, Huang X, Zhang J, Bai R, Zhuang L, Wen S, Wu S, Zhou Q, Li M, Zeng L, Zhang S, Deng S, Su J, Zuo Z, Chen R, Lin D*, Zheng J*. Super-enhancer RNA m6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma. Nature Genetics. 2023 Dec;55(12):2224-2234.
3.Chang J, Zhao X, Wang Y, Liu T, Zhong C, Lao Y, Zhang S, Liao H, Bai F, Lin D*, Wu C*. Genomic alterations driving precancerous to cancerous lesions in esophageal cancer development. Cancer Cell. 2023 Dec;41(12):2038-2050.e5.
4.Chen Y, Zhu S, Liu T, Zhang S, Lu J, Fan W, Lin L, Xiang T, Yang J, Zhao X, Xi Y, Ma Y, Cheng G, Lin D*, Wu C*. Epithelial cells activate fibroblasts to promote esophageal cancer development. Cancer Cell. 2023 May;41(5):903-918.e8.
5.Deng S, Zhang J, Su J, Zuo Z, Zeng L, Liu K, Zheng Y, Huang X, Bai R, Zhuang L, Ye Y, Li M, Pan L, Deng J, Wu G, Li R, Zhang S, Wu C, Lin D*, Chen J*, Zheng J*. RNA m6A formation coupled with DNA demethylation in chromatin accessibility and gene transcription regulation. Nature Genetics. 2022 Sep;54(9):1427-1437.
6.Li R, Di L, Li J, Fan W, Liu Y, Guo W, Liu W, Liu L, Li Q, Chen L, Chen Y, Miao C, Liu H, Wang Y, Ma Y, Xu D, Lin D*, Huang Y*, Wang J*, Bai F*, Wu C*. A body map of somatic mutagenesis in morphologically normal human tissues. Nature. 2021 Sep;597(7876):398-403.
7.Zheng J, Huang X, Tan W, Yu D, Du Z, Chang J, Wei L, Han Y, Wang C, Che X, Zhou Y, Miao X, Jiang G, Yu X, Yang X, Cao G, Zuo C, Li Z, Wang C, Cheung ST, Jia Y, Zheng X, Shen H, Wu C*, Lin D*. Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nature Genetics. 2016 Jul;48(7):747-57.
8.Wei Q, Yu D, Liu M, Wang M, Zhao M, Liu M, Jia W, Ma H, Fang J, Xu W, Chen K, Xu Z, Wang J, Tian L, Yuan H, Chang J, Hu Z, Wei L, Huang Y, Han Y, Liu J, Han D, Shen H, Yang S, Zheng H, Ji Q, Li D, Tan W, Wu C, Lin D*. Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Nature Genetics. 2014 Oct;46(10):1110-4.
9.Wu C, Miao X, Huang L, Che X, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Zhai K, Chang J, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Xu J, Tan W, Zhao P, Wu T, Wang C, Lin D*. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nature Genetics. 2011 Dec;44(1):62-6.
10.Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y, Liu Z, Zhan Q, Liu Y, Yu D, Zhai K, Chang J, Qiao Y, Jin G, Liu Z, Shen Y, Guo C, Fu J, Miao X, Tan W, Shen H, Ke Y, Zeng Y, Wu T, Lin D*. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nature Genetics. 2011 Jun;43(7):679-84.
