LIN Dongxin

General Information

Professor Dongxin Lin

Cancer Center and the State Key Laboratory of Oncology in Southern China

Sun Yat-sen University, Guangzhou, China

E-mail: lindx@sysucc.org.cn

Education

1977-1982: Medical Student, Shanghai Medical University, Shanghai, China

1983-1986: Medical Graduate Student, Beijing Medical University, Beijing, China

Professional Experience

1987-1988 Assistant Professor, Fujian Medical College; Fuzhou, China.

1988-1990 Visiting Scientist, International Agency for Research on Cancer, Lyon, France.

Metabolic Activation and Carcinogen-DNA Adduct Detection.

1990-1994 Postdoctoral Fellow, Office of Research, National Center for Toxicological Research, US FDA, Jefferson, Arkansas, USA.

Metabolic Activation and Carcinogen-DNA Adduct Characterization.

1995-1996 Associate Professor, Department of Etiology & Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Carcinogenesis and Molecular Epidemiology of Cancer

1996-1997 Visiting Scientist, Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas, USA.

Carcinogenesis and Molecular Epidemiology of Cancer

1997-Present Professor and Director, Department of Etiology & Carcinogenesis, Cancer Institute, Chinese Academy of Medical

Sciences and Peking Union Medical College, Beijing, China.

2015-Present Professor, Cancer Center and the State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China.

2013- Present Academician of the Chinese Academy of Engineering

Professional Societies

American Association for Cancer Research, active member

Chinese Anticancer Association, Member of Council

Emeritus chair of Sub-association of Cancer Etiology, Chinese Anticancer Association

National Academic Awards and Honors

2013: The 1nd Prize, the National Sci-Tech Advance Award of China (Personal ranking No. 6).

2013: The 2nd Prize, the National Natural Science Award of China (Personal ranking No. 4)

2011: The 1st Prize, Natural Science Award of Ministry of Education of China (Personal ranking No. 1)

2008: The 2nd Prize, the National Sci-Tech Advance Award of China (Personal ranking No. 3).

2006: The 2nd Prize, the National Natural Science Award of China (Personal ranking No. 1)

Research Interests

The molecular mechanism of tumorigenesis and its genetic susceptibility; the interaction between cancer susceptibility genes and environment; the effect of genetic variants on treatment efficacy and prognosis of cancer patients.

Select Publications (*corresponding author)

1 Liu C, Guo H, Cheng X, Shao M, Wu C, Wang S, Li H, Wei L, Gao Y, Tan W, Cheng S, Wu T*, Yu D*, Lin D* (2015). Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells. Oncotarget 6:29428–39.

2 Jin G, Zhu M, Yin R, Shen W, Liu J, Sun J, Wang C, Dai J, Ma H, Wu C, Yin Z, Huang J, Higgs BW, Xu L, Yao Y, Christiani DC, Amos CI, Hu Z, Zhou B, Shi Y*, Lin D*, Shen H* (2015). Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in chinese populations. Am J Hum Genet 96:832–840.

3 Wei Q*, Yu D, Liu M, Wang M, Zhao M, Liu M, Jia W, Ma H, Fang J, Xu W, Chen K, Xu Z, Wang J, Tian L, Yuan H, Chang J, Hu Z, Wei L, Huang Y, Han Y, Liu J, Han D, Shen H, Yang S, Zheng H, Ji Q, Lin D, Tan W, Wu C*, Lin D (2014). Genome-wide association study identifies three susceptibility loci for laryngeal squamous-cell carcinoma in Chinese population. Nat Genet 46:1110–1114.

4 Wu C, Wang Z, Song X, Feng XS, Abnet CC, He J, Hu N, Zuo XB, Tan W, Zhan Q, Hu Z, He Z, Jia W, Zhou Y, Yu K, Shu XO, Yuan JM, Zheng W, Zhao XK, Gao SG, Yuan ZQ, Zhou FY, Fan ZM, Cui JL, Lin HL, Han XN, Li B, Chen X, Dawsey SM, Liao L, Lee MP, Ding T, Qiao YL, Liu Z, Liu Y, Yu D, Chang J, Wei L, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Han JJ, Zhou SL, Zhang P, Zhang DY, Yuan Y, Huang Y, Liu C, Zhai K, Qiao Y, Jin G, Guo C, Fu J, Miao X, Lu C, Yang H, Wang C, Wheeler WA, Gail M, Yeager M, Yuenger J, Guo ET, Li AL, Zhang W, Li XM, Sun LD, Ma BG, Li Y, Tang S, Peng XQ, Liu J, Hutchinson A, Jacobs K, Giffen C, Burdette L, Fraumeni JF Jr, Shen H, Ke Y, Zeng Y, Wu T, Kraft P, Chung CC, Tucker MA, Hou ZC, Liu YL, Hu YL, Liu Y, Wang L, Yuan G, Chen LS, Liu X, Ma T, Meng H, Sun L, Li XM, Li XM, Ku JW, Zhou YF, Yang LQ, Wang Z, Li Y, Qige Q, Yang WJ, Lei GY, Chen LQ, Li EM, Yuan L, Yue WB, Wang R, Wang LW, Fan XP, Zhu FH, Zhao WX, Mao YM, Zhang M, Xing GL, Li JL, Han M, Ren JL, Liu B, Ren SW, Kong QP, Li F, Sheyhidin I, Wei W, Zhang YR, Feng CW, Wang J, Yang YH, Hao HZ, Bao QD, Liu BC, Wu AQ, Xie D, Yang WC, Wang L, Zhao XH, Chen SQ, Hong JY, Zhang XJ, Freedman ND, Goldstein AM, Lin D*, Taylor PR*, Wang LD*, Chanock SJ (2014). Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Nat Genet 46:1001–1006

5 Chen K, Ma H, Li L, Zang R, Wang C, Song F, Shi T, Yu D, Yang M, Xue W, Dai J, Li S, Zheng H, Wu C, Zhang Y, Wu X, Li D, Xue F, Li H, Jiang Z, Liu J, Liu Y, Li P, Tan W, Han J, Jie J, Hao Q, Hu Z, Lin D, Ma D, Jia W, Shen H, Wei Q* (2014). Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women. Nat Commun 19;5:4682.

6 Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X,Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J,Ma L, Zhao J, Luo L, Fu M, Xu B, Chen B, Li Y, Tong T,Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q (2014). Identification of genomic alterations in oesophageal squamous cell cancer. Nature 509:91–95.

7 Wu C, Kraft P, Stolzenberg-Solomon R, Steplowski E, Brotzman M, Xu M, Mudgal P, Amundadottir L, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, Kooperberg C, Petersen GM, Zheng W, Albanes D, Boutron-Ruault M-C, Buring JE, Canzian F, Cao G, Duell EJ, Elena JL, Gaziano JM…Fuchs CS, Lin D*, Wolpin BM* (2014). Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut 63:152–160.

8 He M*, Wu C*, Xu J*, Guo H*, Yang H, Zhang X, Sun J, Yu D, Zhou L, Peng T, He Y, Gao Y, Yuan J, Deng Q, Dai X, Tan A, Feng Y, Zhang H, Min X, Yang X, Zhu J, Zhai K, Chang J, Qin X, Tan W, Hu Y, Lang M, Tao S, Li Y, Li Y, Feng J, Li D, Kim ST, Zhang S, Zhang H, Zheng SL, Gui L, Wang Y, Wei S, Wang F, Fang W, Liang Y, Zhai Y, Chen W, Miao X, Zhou G, Hu FB, Lin D*, Mo Z*, Wu T* (2014). A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Gut 63:143–151 (*contributed equally to this study)

9 Tan DE, Foo JN, Bei JX, Chang J, Peng R, Zheng X, Wei L, Huang Y, Lim WY, Li J, Cui Q, Chew SH, Ebstein RP, Kuperan P, Lim ST, Tao M, Tan SH, Wong A, Wong GC, Tan SY, Ng SB, Zeng Y, Khor CC, Lin D*, Seow AL*, Jia W*, Liu J* (2013). Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nat Genet 45:804–807.

10 Wu C, Li D, Jia W, Hu Z, Zhou Y, Yu D, Tong T, Wang M, Lin D, Qiao Y, Zjou Y, Chang J, Zhai K, Wang M, Wei L, Tan W, Shen H, Zeng Y, Lin D* (2013). Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma patients. Nat Genet 45:632–638.

11 Wu C, Chang J, Ma B, Miao X, Zhou Y, Liu Y, Li Y, Wu T, Hu Z, Shen H, Jia W, Zeng Y, Lin D*, Kraft P* (2013). The case-only test of gene-environment interaction is not uniformly powerful: An empirical example. Genet Epidemiol 37:402–407.

12 Dong J, Jin G, Wu C, Guo H, Zhou B, Lv J, Lu D, Shi Y, Shu Y, Xu L, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Yu D, Ma H, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Cao S, Qin Z, Gong J, Sun C, Wang J, Wu W, Zhou G, Chen H, Guan P, Chen Y, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Liu J, Amos CI, Chen F, Tan W, Jin L, Wu T, Hu Z*, Lin D*, Shen H* (2013). Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in Han Chinese. PLoS Genet 9:e1003190.

13 Huang L, Wu C, Yu D, Wang C, Che X, Miao X, Zhai K, Chang J, Jiang G, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Tan W, Wu T, Lin D* (2013). Identification of common variants in BRCA2 and MAP2K4 for susceptibility to sporadic pancreatic cancer. Carcinogenesis 34:1001–1005.

14 Jiang DK, Sun J, Cao G, Liu Y, Lin D, Gao YZ, Ren WH, Long XD, Zhang H, Ma XP, Wang Z, Jiang W, Chen TY, Gao Y, Sun LD, Long JR, Huang HX, Wang D, Yu H, Zhang P, Tang LS, Peng B, Cai H, Liu TT, Zhou P, Liu F, Lin X, Tao S, Wan B, Sai-Yin HX, Qin LX, Yin J, Liu L, Wu C, Pei Y, Zhou YF, Zhai Y, Lu PX, Tan A, Zuo XB, Fan J, Chang J, Gu X, Wang NJ, Li Y, Liu YK, Zhai K, Zhang H, Hu Z, Liu J, Yi Q, Xiang Y, Shi R, Ding Q, Zheng W, Shu XO, Mo Z, Shugart YY, Zhang XJ, Zhou G, Shen H, Zheng SL, Xu J*, Yu L* (2012). Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat Genet 45:72–75. (co-first author)

15 Wu C, Kraft P, Zhai K, Chang J, Zhao W, Li Y, Hu Z, He Z, Jia W, Abnet CC, Liang L, Hu N, Miao X, Zhou Y, Liu Z, Zhan Q, Liu Y, Qiao Y, Zhou Y, Jin G, Guo C, Lu C, Yang H, Fu J, Yu D, Freedman ND, Ding T, Tan W, Goldstein AM, Wu T, Shen H, Ke Y, Zeng Y, Chanock SJ, Taylor PR, Lin D* (2012). Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet 44:1090–1097.

16 Lan Q, Hsiung CA, Matsuo K, …, Wu T*, Wu Y*, Yang P-C*, Zhou B*, Shin M-H*, Fraumeni Jr F*, Lin D*, Chanock SJ*, Rothman N* (2012). Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet 44:1330– 1335 (*jointly directed this study).

17 Jin G, Ma H, Wu C, Dai J, Zhang R, Shi Y, Lu J, Miao X, Wang M, Zhou Y, Chen J, Li H, Pan S, Chu M, Yu D, Jiang Y, Dong J, Hu L, Chen Y, Xu L, Shu Y, Pan S, Tan W, Zhou B, Lu D, Wu T, Zhang Z, Chen F, Wang X, Hu Z*, Lin D*, Shen H (2012). Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers: evidence from three genome-wide association studies on different cancers in Han Chinese populations. Am J Hum Genet 91:928–934.

18 Zhai K, Tian X, Wu C, Lu N, Chang J, Huang L, Zhang T, Zhou Y, Qiao Y, Yu D, Tan W, Chen J*, Lin D* (2012). Cytokine BAFF gene variation is associated with survival of patients with T-cell lymphoma. Clin Cancer Res 18:2250–2256.

19 Wu C, Miao X, Huang L, Che C, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Zhai K, Chang J, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Xu J, Tan W, Zhao P, Wu T, Wang C*, Lin D* (2012). Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet 44:62–66.

20 Huang L, Yu D, Wu C, Zhai K, Jiang G, Cao G, Wang C, Liu Y, Sun M, Li Z, Tan W, Lin D* (2012). Copy number variation at 6q13 functions as a long-range regulator and is associated with pancreatic cancer risk. Carcinogenesis 33:94–100.

21 Guo H, Deng Q, Wu C, Hu L, Wei S, Xu P, Kuang D, Liu L, Hu Z, Miao X, Shen H, Lin D, Wu T* (2011). Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations. Cancer Res 71:7576–7586.

22 Shi Y*, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Hu L, Jiang Y, Li Z, Chu M, Ma H, Chen J, Jin G, Tan W, Wu T, Zhang Z, Lin D*, Shen H* (2011). A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet 43:1215–1218.

23 Hu Z, Wu C, Shi Y, Guo H, Zhao X, Yin Z, Yang L, Dai J, Hu L, Tan W, Li Z, Deng Q, Wang J, Wu W, Jin G, Jiang Y, Yu D, Zhou G, Chen H, Guan P, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Ma H, Chen J, Chu M, Lu F, Zhang Z, Chen F, Wang X, Jin L, Lu J, Zhou B, Lu D, Wu T, Lin D, Shen H* (2011). A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet 43:792–796.

24 Xiong F, Wu C, Chang J, Yu D, Xu B, Yuan P, Zhai K, Xu J, Tan W, Lin D* (2011). Genetic variation in MiRNA-1827 binding site of MYCL1 and susceptibility to small-cell lung cancer. Cancer Res 71:5175–5181.

25 Wu C, He Z, Hu Z, Jia W, Wang F, Liu Z, Zhan Q, Liu Y, Yu D, Liu Z, Shen Y, Zhai K, Chang J, Qiao Y, Guo C, Jin G, Fu J, Miao X, Tan W, Wu T, Ke Y, Shen H, Zeng Y, Lin D* (2011). Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet 43:679–684.

26 Knappskog S, Bjørnslett M, Myklebust LM, Huijts PE, Vreeswijk MP, Edvardsen H, Guo Y, Zhang X, Yang M, Ylisaukko-Oja SK, Alhopuro P, Arola J, Tollenaar RA, van Asperen CJ, Seynaeve C, Staalesen V, Chrisanthar R, Løkkevik E, Salvesen HB, Evans DG, Newman WG, Lin D, Aaltonen LA, Børresen-Dale AL, Tell GS, Stoltenberg C, Romundstad P, Hveem K, Lillehaug JR, Vatten L, Devilee P, Dørum A, Lønning PE (2011). The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians. Cancer Cell 19:273–282.

27 Wu C, Xu B, Yuan P, Miao X, Liu Y, Guan Y, Yu D, Xu J, Zhang T, Shen H, Wu T, Lin D* (2010). Genome-wide interrogation identifies YAP1 variants associated with survival of small-cell lung cancer patients. Cancer Res 70:9721–9729.

28 Hsiung CA, Lan Q*, Hong YC, Chen CJ, Hosgood HD, Chang IS, Chatterjee N, Brennan P, Wu C, Zheng W, Chang GC, Wu T, Park JY, Hsiao CF, Kim YH, Shen H, Seow A, Yeager M, Tsai YH, Kim YT, Chow WH, Guo H, Wang WC, Sung SW, Hu Z, Chen KY, Kim JH, Chen Y, Huang L, Lee KM, Lo YL, Gao YT, Kim JH, Liu L, Huang MS, Jung TH, Jin G, Caporaso N, Yu D, Kim CH, Su WC, Shu XO, Xu P, Kim IS, Chen YM, Ma H, Shen M, Cha SI, Tan W, Chang CH, Sung JS, Zhang M, Yang TY, Park KH, Yuenger J, Wang CL, Ryu JS, Xiang Y, Deng Q, Hutchinson A, Kim JS, Cai Q, Landi MT, Yu CJ, Park JY, Tucker M, Hung JY, Lin CC, Perng RP, Boffetta P, Chen CY, Chen KC, Yang SY, Hu CY, Chang CK, Fraumeni JF Jr, Chanock S, Yang PC, Rothman N, Lin D (2010). The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet 6(8):e1001051.

29 Zhang H, Zhai Y, Hu Z, Wu C, Qian J, Jia W, Ma F, Huang W, Yu L, Yue W, Wang Z, Li P, Zhang Y, Liang R, Wei Z, Cui Y, Xie W, Cai M, Yu X, Yuan Y, Xia X, Zhang X, Yang H, Qiu W, Yang J, Gong F, Chen M, Shen H, Lin D, Zeng Y, He F*, Zhou G* (2010). Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet 42;755–758.

30 Bi N, Yang M, Zhang L, Chen X, Ji W, Ou G, Lin D*, Wang L* (2010). Cyclooxygenase-2 genetic variants are associated with survival in unrsectable locally advanced non-small-cell lung cancer. Clin Cancer Res 16:2383–2390.

31 Yang M, Guo H, Wu C, He Y, Yu D, Zhou L, Wang F, Xu J, Tan W, Wang G, Shen B, Yuan J, Wu T, Lin D* (2009). Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk. Hum Mutat 30:1320–1328.

32 Sun T, Hu Z, Shen H, Lin D* (2009). Genetic polymorphisms in cytotoxic T-lymphocyte antigen 4 and cancer: the dialectical nature of subtle human immune deregulation. Cancer Res 69:6011–6014.

33 Wu C, Hu Z, Yu D, Huang L, Jin G, Liang J, Guo H, Tan W, Zhang M, Qian J, Lu D, Wu T, Lin D*, Shen H* (2009). Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. Cancer Res 69:5065–5072.

34 Zhao D, Xu D, Zhang X, Wang L, Tan W, Guo Y, Yu D, Li H, Zhao P*, Lin D* (2009). Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: A possible role of nucleophosmin. Gastroenterology 136:1659–1668.

35 Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D*, Liu Z* (2009). Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma. Cancer Res 69:3451–3457.

36 Sun T, Zhou Y, Yang M, Hu Z, Tan W, Han X, Shi Y, Yao J, Guo Y, Yu D, Tian T, Zhou X, Shen H*, Lin D* (2008). Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer. Cancer Res 68:7025–7034.

37 Yang M, Sun T, Wang L, Yu D, Zhang X, Miao X, Liu J, Zhao D, Li H, Tan W, Lin D* (2008). Functional variants in cell death pathway genes and risk of pancreatic cancer. Clin Cancer Res 14:3230–3236.

38 Yu D, Zhang X, Liu J, Yuan P, Tan W, Guo Y, Sun T, Zhao D, Ming Y, Liu J, Xu B*, Lin D* (2008). Characterization of functional excision repair cross-complementation group 1 variants and their association with lung cancer risk and prognosis. Clin Cancer Res 14: 2878–2886.

39 Lin Z, Zhang X, Tu J, Guo Y, Green B, Chan C, Tan W, Huang Y, Ling W, Kadlubar FF, Lin D*, Ning B* (2008). A variant of the Cokyne syndrome B gene ERCC6 confers risk of lung cancer. Hum Mutat 29:113–122.

40 Li Z, Dai H, Zhou M, Li M, Singh P, Qiu J, Tsark W, Huang Q, Kernstine K, Zhang X, Lin D, Shen B* (2007). Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat Med 13:812–819.

41 Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q, Zeng C*, Lin D* (2007). A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nat Genet 39:605–613.

42 Zhao D, Sun T, Zhang X, Guo Y, Yu D, Yang M, Tan W, Wang G, Lin D* (2007). Role of CD14 promoter polymorphisms in Helicobacter pylori infection related gastric carcinoma. Clin Cancer Res 13:2362–2368.

43 Sun T, Gao Y, Tan W, Ma S, Zhang X, Wang Y, Zhang Q, Guo Y, Zhao D, Zeng C*, Lin D* (2006). Haplotypes in matrix metalloproteinase gene cluster on chromosome 11q22 contribute to the risk of lung cancer development and progression. Clin Cancer Res 12:7009–7017.

44 Miao X, Zhang X, Zhang L, Guo Y, Hao B, Tan W, He F*, Lin D* (2006). Adenosine diphosphate ribosyl transferase and X-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer. Gastroenterology 131:420–427.

45 Hao B, Miao X, Li Y, Zhang X, Sun T, Liang G, Zhao Y, Zhou Y, Wang H, Chen X, Zhang L, Tan W, Wei Q, Lin D*, He F* (2006). A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene 25:3613–3620.

46 Zhang X, Miao X, Guo Y, Xu N, Hong Y, Liu Z, Tan W, Lin D* (2006). Genetic polymorphisms in cell cycle regulatory genes MDM2 and P53 are associated with susceptibility to lung cancer risk. Hum Mutat 27:110–117.

47 Sun T, Zhou Y, Li H, Han X, Shi Y, Wang L, Miao X, Tan W, Zhao D, Zhang X, Guo Y, Lin D* (2005). FASL-844C polymorphism is associated with increased activation induced T-cell death and risk of cervical cancer. J Exp Med 202:967–974.

48 Hong Y, Miao X, Zhang X, Guo Y, Tan W, Liu Z*, Lin D* (2005). The role of P53 and MDM2 polymorphisms in risk of esophageal squamous cell carcinoma. Cancer Res 65:9582–9587.

49 Zhang X, Miao X, Tan W, Ning B, Liu Z, Hong Y, Song W, Guo Y, Zhang X, Shen Y, Qiang B, Kadlubar FF, Lin D* (2005). Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Gastroenterology 129:565–576.

50 Zhang X, Miao X, Liang G, Hao B, Wang Y, Tan W, Li Y, Guo Y, He F, Wei Q, Lin D* (2005). Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. Cancer Res 65:722–726.

51 Yu C, Zhou Y, Miao X, Xiong P, Tan W, Lin D* (2004). Functional haplotypes in the promoter of matrix metalloproteinase-2 predict risk of occurrence and metastasis of esophageal cancer. Cancer Res 64:7622–7628.

52 Hao B, Wang H, Zhou K, Li Y, Chen X, Zhou G, Zhu Y, Miao X, Tan W, Wei Q, Lin D, He F* (2004). Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. Cancer Res 64:4378–4384.

53 Sun T, Miao X, Zhang X, Tan W, Xiong P, Lin D* (2004). Polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinoma. J Natl Cancer Inst 96: 1030–1036.

54 Miao X, Sun T, Wang Y, Zhang X, Tan W, Lin D* (2004). Functional STK Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma. Cancer Res 64:2680–2683.

55 Wang H, Tan W, Hao B, Miao X, Zhou G, He F, Lin D* (2003). Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. Cancer Res 63:8057–8061.

56 Miao X, Yu C, Tan W, Xiong P, Liang G, Lu W, Lin D* (2003). A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma. Cancer Res 63: 3987–3990.

57 Lin D, Thompson P, Teitel C, Chen J, Kadlubar FF* (2003). Direct reduction of N-acetoxy-PhIP by tea polyphenols: a possible mechanism for chemoprevention against PhIP-DNA adduct formation. Mutat Res 523-524:193–200.

58 Yu C, Pan K, Xing D, Liang G, Tan W, Zhang L, Lin D* (2002). Correlation between a single nucleotide polymorphism in the matrix metalloproteinase-2 promoter and risk of lung cancer. Cancer Res 62:6430–6433.

59 Song C, Xing D, Tan W, Wei Q, Lin D* (2001). Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Res 61:3272–3275.

60 Song N, Tan W, Xing D, Lin D* (2001). CYP1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: A case-control study in China. Carcinogenesis 22:11–16.

61 Lin D, Tang Y, Pen Q, Lu S, Ambrosone CB, Kadlubar FF* (1998). Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1. Cancer Epidemiol Biomarkers Prev 7:1013–1018.

62 Lin D, Lang N, Kadlubar FF* (1995). Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by hepatic microsomes and cytosols from human, rats, and mice. Drug Metab Dispos 23:518–524.

63 Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF* (1994). Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: possible mechanism of organ specificity in their carcinogenesis. Cancer Res 54:4920–4926.

64 Lin D, Lay JO, Bryant MS, Malaveille C, Friesen M, Bartsch H, Lang NP, Kadlubar FF* (1994). Analysis of 4-aminobiphenyl-DNA adducts in human urinary bladder and lung by alkaline hydrolysis and negative ion gas chromatography-mass spectrometry. Environ Health Perspect 102 (Suppl 6):11–16.

65 Lin D, Kaderlik KR, Turesky RJ, Miller DW, Lay JO, Kadlubar FF* (1992). Identification of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenyl-imidazo[4,5-b] pyridine, with DNA. Chem Res Toxicol 5:691–697.

66 Lin D, Friesen MD, Malaveille C, Shuker DEG, Bartsch H* (1991). Urinary excretion of S-benzylmercapturic acid as an indicator of N-nitroso-N-methylbenzylamine exposure. Cancer Lett 57:193–198.

67 Lin D, Malaveille C, Park SS, Gelboin HV, Bartsch H* (1990). Contribution of DNA methylation and benzylation to N-nitroso-N-benzylmethylamine induced mutagenesis in bacteria: effects of rat liver cytochrome P450 isozymes and glutathione transferases. Carcinogenesis 11:1653–1658.